2. Cardiovascular Disease

Cardiovascular Disease

Cardiovascular Disease

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Cardiovascular diseases (CVDs) are the leading causes of death and disability worldwide. CVDs include diseases of the heart, vascular diseases of the brain and diseases of blood vessels. Caused by atherosclerosis, coronary heart disease and cerebrovascular disease are the most common forms of CVDs. Other less common forms of CVDs include rheumatic heart disease and congenital heart disease. A large percentage of CVDs is preventable through the reduction of behavioral risk factors such as tobacco use, physical inactivity and unhealthy diet. Dietary sodium reduction can alleviate the long-term risk of cardiovascular disease events. Statin therapy is an effective intervention in both the primary and secondary preventions of CVDs in those who are at high risk.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-P1534
    Adrenomedullin (1-50), rat 161383-47-7 99.56%
    Adrenomedullin (1-50), rat is a 50 amino acid peptide, which induces a selective arterial vasodilation via activation of CGRP1 receptor.
    Adrenomedullin (1-50), rat
  • HY-P2008
    Boc-Ile-Glu-Gly-Arg-AMC 65147-06-0 99.50%
    Boc-Ile-Glu-Gly-Arg-AMC (IEGR-AMC) is an activated factor X (FXa) specific fluorogenic peptide substrate used for Factor VIII determination.
    Boc-Ile-Glu-Gly-Arg-AMC
  • HY-P2222
    DX600 478188-26-0 99.93%
    DX600 is a selective ACE2 specific inhibitor (KD: 1.3 nM), and does not cross-react with ACE. DX600 exacerbates diabetes-induced cardiovascular dysfunction and the increase in cardiac and renal NOX activity.
    DX600
  • HY-P2491
    Atrial Natriuretic Peptide (1-28), human, porcine, Biotin-labeled 1815618-06-4 99.81%
    Atrial Natriuretic Peptide (1-28), human, porcine, Biotin-labeled, one of three mammalian natriuretic peptides (NPs), has endocrine effects on fluid homeostasis and blood pressure. Atrial Natriuretic Peptide has the potential for cardiovascular diseases research.
    Atrial Natriuretic Peptide (1-28), human, porcine, Biotin-labeled
  • HY-100589
    Isepamicin sulfate 67814-76-0 98.0%
    Isepamicin sulfate (Sch 21420 sulfate) is a broad-spectrum aminoglycoside antibiotic. Isepamicin sulfate has considerable antimicrobial activity against some Gram-negative non-fermenting bacteria that are highly resistant to antibiotics. Isepamicin sulfate inhibits writhing reactions induced by Acetic acid (HY-Y0319), regulates vascular blood flow and blood pressure, and inhibits spontaneous uterine movements. Isepamicin sulfate has antidiuretic and blood sugar-raising effects. Isepamicin sulfate can be used in seizure research.
    Isepamicin sulfate
  • HY-101832
    SBC-110736 1629166-02-4 99.55%
    SBC-110736 is a proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitor extracted from patent WO2014150395A1.
    SBC-110736
  • HY-103189
    VUF-5574 280570-45-8 99.0%
    VUF-5574 is a selective antagonist of adenosine A3 receptor with a Ki of 4.03 nM for the recombinant human receptor.
    VUF-5574
  • HY-103460
    IRL 2500 169545-27-1 99.27%
    IRL 2500 is a potent Endothelin receptor antagonist. IRL 2500 shows IC50 values of 1.3 and 94 nM for ETB and ETA receptors, respectively. IRL 2500 inhibits ETB receptor-mediated blood pressure increase and renal vascular resistance in rats in vivo.
    IRL 2500
  • HY-107428
    PD-166793 199850-67-4 99.21%
    PD-166793 is a potent, selective, orally active and wide-broad spectrum inhibitor of MMP, exhibiting nanomolar potency against MMP-2, MMP-3 and MMP-13 (IC50=4, 7, and 8 nM, respectively) and micromolar potency vs MMP-1, -7 and -9 (IC50=6.0, 7.2, and 7.9 μM, respectively). PD-166793 can attenuate left ventricular remodeling and dysfunction in a rat model of progressive heart failure.
    PD-166793
  • HY-107580
    GPR109 receptor agonist-1 306935-41-1 99.94%
    GPR109 receptor agonist-1 (Compound 3a) is a highly selective agonist of the human orphan G-protein-coupled receptor GPR109b, with the pEC50 of 6.4. GPR109 receptor agonist-1 can be used for the research of cardio-metabolic diseases.
    GPR109 receptor agonist-1
  • HY-107637
    ONO-4817 223472-31-9 ≥98.0%
    ONO-4817 is a potent inhibitor of matrix metalloproteinase (MMP). Inhibition of matrix metalloproteinases (MMPs) is expected to suppress atherosclerotic neointimal proliferation and thus limits atheromatous plaque progression. ONO-4817 suppresses the development of aortic intimal hyperplasia in experimental hyperlipidemic rabbit.
    ONO-4817
  • HY-107929
    Calcium polystyrene sulfonate 37286-92-3
    Calcium polystyrene sulfonate (Poly(styrenesulfonic acid) calcium salt) is an orally active ion-exchange resin. Calcium polystyrene sulfonate can reduce the potassium content in the blood. Calcium polystyrene sulfonate can be used in the research of hyperkalemia caused by chronic kidney disease.
    Calcium polystyrene sulfonate
  • HY-111024
    2,2,5,7,8-Pentamethyl-6-Chromanol 950-99-2 99.30%
    2,2,5,7,8-Pentamethyl-6-Chromanol (PMC) is the anti-oxidant moiety of vitamin E (α-tocopherol). 2,2,5,7,8-Pentamethyl-6-Chromanol has potent androgen receptor (AR) signaling modulation and anti-cancer activity against prostate cancer cell lines.
    2,2,5,7,8-Pentamethyl-6-Chromanol
  • HY-112627
    CAY 10465 688348-33-6 98.30%
    CAY 10465 is a selective and high-affinity AhR agonist, with a Ki of 0.2 nM, and shows no effect on estrogen receptor (Ki >100000 nM).
    CAY 10465
  • HY-114782
    H-Tyr-Tyr-OH 1050-28-8
    H-Tyr-Tyr-OH (L-Tyrosyl-L-tyrosine) is an antihypertensive peptide. H-Tyr-Tyr-OH inhibits angiotensin I-converting enzyme (ACE) with an IC50 value of 0.028 mg/mL. H-Tyr-Tyr-OH can be used for the research of high blood pressure.
    H-Tyr-Tyr-OH
  • HY-116513
    Adrenochrome 54-06-8 98.66%
    Adrenochrome (Adraxone) is an oxidation product of Epinephrine. Adrenochrome is a potent coronary constricting agent in the rat heart. Adrenochrome can be used for neurological disorder research.
    Adrenochrome
  • HY-117820
    TASP0390325 1642187-96-9 ≥99.0%
    TASP0390325 is a high affinity and orally active arginine vasopressin receptor 1B (V1B receptor) antagonist with antidepressant and anxiolytic activities.
    TASP0390325
  • HY-117970
    MMPI-1154 1382722-47-5 99.87%
    MMPI-1154 is a promising novel cardio-cytoprotective imidazole-carboxylic acid (ICA) MMP-2 inhibitor(IC50=6.6 μM) and can be used for the study of acute myocardial infarction. MMPI-1154 also inhibits the activity of MMP-13, MMP-1 and MMP-9 with IC50s of 1.8 μM,10 μM, and 13 μM, respectively.
    MMPI-1154
  • HY-118060
    Dipeptide 2 24587-37-9
    Dipeptide 2 (N-Valyltryptophan; Val-Trp) is a bioactive peptide with anti-aging effect and has been reported used as a cosmetic ingredient. Dipeptide 2 is an angiotensin-converting Enzyme (ACE).
    Dipeptide 2
  • HY-119964
    Cetaben 55986-43-1 99.41%
    Cetaben is a PPARα-independent peroxisome proliferator. Cetaben is a non-fibrate hypolipidemic agent and potently reduces the concentration of cholesterol and triglycerides.
    Cetaben
Cat. No. Product Name / Synonyms Application Reactivity